血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)重組蛋白
Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)
ADMP-1; Aggrecanase-1
- 編號RPK204Hu01
- 物種Homo sapiens (Human，人)相同的名稱，不同的物種。
- 來源原核表達
- 宿主E.coli
- 內毒素水平<1.0EU/µg(LAL法測定)
- 亞細胞定位分泌, 細胞外基質
- 預測分子量16.4kDa
- 實際分子量17kDa(差異分析請參閱說明書)
- 片段與標簽Thr437~Pro575 with N-terminal His Tag
- 緩沖液成份PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- 性狀凍干粉
- 純度> 95%
- 等電點7.6
- 應用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請參見活性蛋白。 - 下載英文說明書 中文說明書
- 規(guī)格10μg50μg200μg1mg5mg
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產品包裝(模擬)
產品包裝(模擬)
SDS-PAGE圖
通過ISO 9001、ISO 13485質量體系認證
序列
用法
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲存
避免反復凍融。2-8°C不超過一個月，-80°C不超過12個月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產生。保質期內，在適當?shù)臈l件下存儲，損失率低于5%。
增值服務
相關產品
| 編號 | 適用物種：Homo sapiens (Human，人) | 應用(僅供研究使用，不用于臨床診斷！) |
| RPK204Hu01 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAK204Hu01 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體 | WB; IHC; ICC; IP. |
| LAK204Hu71 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體(生物素標記) | WB; IHC; ICC. |
| LAK204Hu81 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體(異硫氰酸熒光素標記) | WB; IHC; ICC; IF. |
| MAK204Hu21 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)單克隆抗體 | WB; IHC; ICC; IP. |
| SEK204Hu | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMK204Hu | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| KSK204Hu01 | 血小板反應蛋白解整合素金屬肽酶4(ADAMTS4)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗法) | 自己動手制作ELISA試劑盒的主要材料 |
參考文獻
| 雜志 | 參考文獻 |
| Biomedicine & Pharmacotherapy | ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes[ScienceDirect: S0753332209002017] |
| PLoS ONE | A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches[Plosone: Source] |
| Anadolu Kardiyol Derg. | A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.[Pubmed:25592103] |
| Osteoarthritis and Cartilage | Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium[PubMed: 26521751] |
| Osteoarthritis and Cartilage | Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized Cavia (Guinea pig )inea pigs[Pubmed:26802547] |
| Journal of Cellular and Molecular Medicine | VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts[Pubmed:26818776] |
| Int Wound J. | From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases.[Pubmed:26991748] |
| The American journal of pathology | Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1β and Fibronectin and Contribution to Cartilage Damage.[pubmed:27449198] |
| International Wound Journal | From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases[pubmed:26991748] |
| American Journal of Translational?Research | Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic?…[Pubmed: 30210670] |
| Journal of Clinical Medicine | The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma?…[Pubmed:35407621] |