細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)重組蛋白
Recombinant Suppressors Of Cytokine Signaling 3 (SOCS3)
ATOD4; CIS3; Cish3; MGC71791; SOCS-3; SSI-3; SSI3; Cytokine-inducible SH2 protein 3; STAT-induced STAT inhibitor 3
- 編號RPB684Mu01
- 物種Mus musculus (Mouse，小鼠)相同的名稱，不同的物種。
- 來源原核表達(dá)
- 宿主E.coli
- 內(nèi)毒素水平<1.0EU/µg(LAL法測定)
- 亞細(xì)胞定位分泌
- 預(yù)測分子量26.3kDa
- 實際分子量26kDa(差異分析請參閱說明書)
- 片段與標(biāo)簽Met1~Leu225 with N-terminal His Tag
- 緩沖液成份20mM Tris, 150mM NaCl緩沖液（pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300）
- 性狀凍干粉
- 純度> 97%
- 等電點(diǎn)8.7
- 應(yīng)用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請參見活性蛋白。 - 下載英文說明書 中文說明書
- 規(guī)格10μg50μg200μg1mg5mg
- 價格¥ 768¥ 1920¥ 3840¥ 11520¥ 28800
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)
Gene sequencing
Figure. SDS-PAGE
通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
序列
用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲存
避免反復(fù)凍融。2-8°C不超過一個月，-80°C不超過12個月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Mus musculus (Mouse，小鼠) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| RPB684Mu02 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB684Mu01 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB684Mu01 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)活性蛋白 | Cell?culture;?Activity?Assays. |
| PAB684Mu02 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)多克隆抗體 | WB; IHC; ICC; IP. |
| PAB684Mu01 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)多克隆抗體 | WB; IHC; ICC; IP. |
| LAB684Mu71 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)多克隆抗體(生物素標(biāo)記) | WB; IHC; ICC. |
| LAB684Mu81 | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)多克隆抗體(異硫氰酸熒光素標(biāo)記) | WB; IHC; ICC; IF. |
| SEB684Mu | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMB684Mu | 細(xì)胞因子信號轉(zhuǎn)導(dǎo)抑制因子3(SOCS3)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻(xiàn)
| 雜志 | 參考文獻(xiàn) |
| The Journal of Biological Chemistry | Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages[Jcb: 280370] |
| The Journal of Biological Chemistry | Human Primary Keratinocytes Show Restricted Ability to Up-regulate Suppressor of Cytokine Signaling (SOCS)3 Protein Compared with Autologous Macrophages[PubMed: PMC3323061] |
| Journal of Reproductive Immunology | What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?[Pubmed: 24368037] |
| The Journal of Immunology | Alveolar Epithelial Cell–Derived Prostaglandin E2?Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation[Pubmed:27183597] |
| Scientific Reports | The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway[pubmed:28970500] |
| Journal of Immunological Methods | Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs.[pubmed:29154772] |
| Turkish?Journal Of?Medical?Sciences | The impact of plasma SOCS3 levels and endometrial leukocytes on unexplained infertility[Pubmed:29914245] |
| Novel trajectories of Bromocriptine antidiabetic action: Leptin-IL-6/JAK2/p-STAT3/SOCS3, p-IR/p-AKT/GLUT4, PPARγ/Adiponectin, Nrf2/PARP-1, and GLP-1[articles:10.3389] | |
| JCI Insight | Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics[Pubmed: 31619584] |
| European Journal of Pharmacology | Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways[Pubmed: 32067934] |
| FASEB JOURNAL | Resident alveolar macrophage‐derived vesicular SOCS3 dampens allergic airway inflammation[Pubmed: 32030817] |
| molecular immunology | SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection[Pubmed: 32645550] |
| Experimental and Therapeutic Medicine | Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with …[Pubmed: 32742411] |
| NEUROCHEMICAL RESEARCH | Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage[33755856] |
| BIOMEDICINE & PHARMACOTHERAPY | Potential contribution of ELISA and LFI Assays to assessment of the oxidative stress condition based on 8-oxodG biomarker[33957564] |